Macrocompression and nanoindentation of soft viscoelastic biological materials.
Tissue Eng Part C Methods
; 18(12): 968-75, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22656195
ABSTRACT
The study of the mechanical behavior of soft biological materials presents many challenges due to the materials' time-dependent mechanical response as well as inherent size and shape limitations. In this study, by using agar as a surrogate material for soft tissues, the effects of these limitations upon standardized macroscale dynamic compression protocols are compared to dynamic nanoindentation procedures. Both techniques are then applied to dynamically test porcine sclera tissue, showing a significant difference in recorded loss and storage modulus values between the two methodologies. Additionally, the tissues of the porcine eye wall are characterized with macrocompression in their layered in vivo arrangement. The overall constraints of standardized macroscale tests for dynamic mechanical characterization of thin and soft biological tissues are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Viscosidade
/
Nanotecnologia
/
Elasticidade
Idioma:
En
Revista:
Tissue Eng Part C Methods
Assunto da revista:
BIOTECNOLOGIA
/
HISTOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos