G-rich sequence-specific recognition and scission of human genome by PNA/DNA hybrid G-quadruplex formation.
Angew Chem Int Ed Engl
; 51(29): 7198-202, 2012 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-22700182
ABSTRACT
Hole in one A single peptide nucleic acid (PNA) effectively targets the G-rich region in double-stranded DNA through formation of a PNA/DNA hybrid G-quadruplex. Only one target site in the whole human genome was selectively cleaved by the hybrid G-quadruplex. Such site-selective scission of DNA is central to gene manipulation for molecular biology, biotechnology, and therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Ácidos Nucleicos Peptídicos
/
Quadruplex G
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão