Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 22(14): 4864-8, 2012 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-22704887
ABSTRACT
Judicious modifications to the structure of the previously reported HCV NS5A inhibitor 1, resulted in more potent anti-HCV compounds with similar and in some cases improved toxicity profiles. The synthesis of 19 new NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. For the most potent compounds chemical stability, stability in liver microsomes and inhibition of relevant CYP450 enzymes is also presented.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Hepacivirus
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos