Altered white matter integrity in young adults with first-episode, treatment-naive, and treatment-responsive depression.
Neurosci Lett
; 522(2): 139-44, 2012 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-22721700
ABSTRACT
Abnormalities of the white matter (WM) tracts integrity in brain areas involved in emotional regulation have been postulated in major depressive disorder (MDD). However, there is no diffusion tensor imaging (DTI) study in patients with treatment-responsive MDD at present. DTI scans were performed on 22 patients with treatment-responsive MDD and 19 well-matched healthy subjects. Tract-based spatial statistics (TBSS) approach was employed to analyze the scans. Voxel-wise statistics revealed four brain WM tracts with lower fractional anisotropy (FA) in patients compared to healthy subjects:
the bilateral internal capsule, the genu of corpus callosum, the bilateral anterior corona radiata, and the right external capsule. FA values were nowhere higher in patients compared to healthy subjects. Our findings demonstrate that the abnormalities of the WM tracts, major in the projection fibers and corpus callosum, may contribute to the pathogenesis of treatment-responsive MDD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Transtorno Depressivo Maior
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Antidepressivos
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China