Synthesis of enantioenriched triarylmethanes by stereospecific cross-coupling reactions.

ABSTRACT

Coupling with inversion Chiral diarylmethanol derivatives undergo a stereospecific nickel-catalyzed cross-coupling reaction with aryl Grignard reagents (see scheme). The reaction proceeds with inversion of configuration and high enantiospecificity. The method has been applied to the asymmetric synthesis of a triarylmethane-based anti-cancer compound.