Severe spinal deformity and multiple vertebral collapses in juvenile Cushing Syndrome: a case report.
Stud Health Technol Inform
; 176: 217-22, 2012.
Article
em En
| MEDLINE
| ID: mdl-22744494
ABSTRACT
Cushing's Syndrome (CS) is rare in adolescence but the pathological effects of excessive circulating glucocorticoids concentration on bone during the developmental age still represent a challenge for orthopedists. Only few reports describe the gravity of early developed damages of spine in young affected by CS. A 18-years-old woman suffering from Cushing's Disease presented after many years treatment of the primary disease referring severe back pain and worsening back deformity. Radiological investigations showed vertebral collapses a devastating thoraco-lumbar scoliosis of 80° Cobb. Lumbar dual X-ray absorptiometry Z-score values were very low and consistent with severe osteoporosis. The patient was treated with bracing, antiresorptive therapy, calcium and vitamin D supplementation, and followed-up with imaging investigations to screen for further fractures. The bone mineral density will be monitored until its normalization will allow to plane surgical treatment in case of progression of spinal deformity and collapses. Early diagnosis and treatment of hypercortisolism, periodical clinical and radiographic follow-up, and treatment for the bone damage are mandatory to prevent the devastating sequelae of secondary osteoporosis.
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Base de dados:
MEDLINE
Assunto principal:
Escoliose
/
Vértebras Torácicas
/
Traumatismo Múltiplo
/
Síndrome de Cushing
/
Fraturas Espontâneas
/
Vértebras Lombares
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Stud Health Technol Inform
Assunto da revista:
INFORMATICA MEDICA
/
PESQUISA EM SERVICOS DE SAUDE
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália