Vitamin D and multiple sclerosis: a critical review and recommendations on treatment.
Acta Neurol Belg
; 112(4): 327-33, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22767049
ABSTRACT
Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Vitaminas
/
Esclerose Múltipla
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Acta Neurol Belg
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos