Effect of substitution at Nâ³-position of N'-hydroxy-N-amino guanidines on tumor cell growth.
Bioorg Med Chem Lett
; 22(15): 4934-8, 2012 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-22781189
ABSTRACT
Structural modification of one of our earlier reported lead molecule (ABNM13) has been carried out to study the effect of different substituents at the Nâ³-position of N-hydroxy-N'-amino guanidines (HAGs) on their anticancer activity. Compounds with electron donating substituents were found to be less active. In contrast, those with electron withdrawing groups were found favorable for anticancer activity. The obtained results provide significant SAR information that may be useful for further drug designing with HAGs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Guanidinas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Índia