Effects of ultrasound and ultrasound contrast agent on vascular tissue.
Cardiovasc Ultrasound
; 10: 29, 2012 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-22805356
ABSTRACT
BACKGROUND:
Ultrasound (US) imaging can be enhanced using gas-filled microbubble contrast agents. Strong echo signals are induced at the tissue-gas interface following microbubble collapse. Applications include assessment of ventricular function and virtual histology.AIM:
While ultrasound and US contrast agents are widely used, their impact on the physiological response of vascular tissue to vasoactive agents has not been investigated in detail. METHODS ANDRESULTS:
In the present study, rat dorsal aortas were treated with US via a clinical imaging transducer in the presence or absence of the US contrast agent, Optison. Aortas treated with both US and Optison were unable to contract in response to phenylephrine or to relax in the presence of acetylcholine. Histology of the arteries was unremarkable. When the treated aortas were stained for endothelial markers, a distinct loss of endothelium was observed. Importantly, terminal deoxynucleotidyl transferase mediated dUTP nick-end-labeling (TUNEL) staining of treated aortas demonstrated incipient apoptosis in the endothelium.CONCLUSIONS:
Taken together, these ex vivo results suggest that the combination of US and Optison may alter arterial integrity and promote vascular injury; however, the in vivo interaction of Optison and ultrasound remains an open question.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aorta Torácica
/
Vasoconstrição
/
Ultrassonografia Doppler de Pulso
/
Meios de Contraste
Limite:
Animals
Idioma:
En
Revista:
Cardiovasc Ultrasound
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos