[Relationship between serum S100B protein level and brain damage in preterm infants].
Zhongguo Dang Dai Er Ke Za Zhi
; 14(7): 485-8, 2012 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-22809597
ABSTRACT
OBJECTIVE:
To study changes of serum S100B protein level in preterm infants with brain damage and its role.METHODS:
Forty-seven preterm infants were classified into 3 groups based on the results of brain ultrasound and MRI brain white matter damage (WMD; n=13), brain but not white matter damage (non-WMD; n=14) and control (no brain damage; n=20). Blood samples were collected within 24 hrs, 72 hrs and 7 days after birth. S100B protein level was measured using ELISA.RESULTS:
Serum levels of S100B in the WMD and non-WMD groups were significantly higher than in the control group within 24 hours, 72 hours and 7 days after birth (P<0.05). More increased serum S100B levels were observed in the WMD group compared with the non-WMD group (P<0.05).CONCLUSIONS:
Serum S100B protein level increases in preterm infants with brain damage within 7 days after birth, suggesting that it may be used as an early sensitive marker for the diagnosis of brain damage, especially WMD.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Recém-Nascido Prematuro
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Proteínas S100
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Fatores de Crescimento Neural
Limite:
Female
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Humans
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Male
/
Newborn
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China