Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: a meta-analysis of epidemiological studies: pesticide exposure as a risk factor for ALS.
Environ Res
; 117: 112-9, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22819005
ABSTRACT
BACKGROUND:
Exposure to pesticides and agricultural chemicals has been linked to amyotrophic lateral sclerosis (ALS) although findings have been inconsistent. A meta-analysis of studies published through May, 2011 was conducted to investigate the association of pesticide exposure and risk of ALS.METHODS:
Six peer-reviewed studies that met criteria were included in a meta-analysis of men involving 1,517 ALS deaths from one retrospective cohort study and 589 ALS or motor neuron disease cases from five case-control studies. A random effects model was used to calculate sex-specific pooled odds ratios (ORs).RESULTS:
Evidence was found for an association of exposure to pesticides and risk of ALS in male cases compared to controls (OR=1.88, 95% CI 1.36-2.61), although the chemical or class of pesticide was not specified by the majority of studies.CONCLUSION:
This meta-analysis supports the relationship of exposure to pesticides and development of ALS among male cases compared to controls. The weight of evidence links pesticide exposure to ALS; however, additional prospective studies with a target exposure group are necessary to better elucidate the relationship. Future research should focus on more accurate exposure assessment and the use of job exposure matrices.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Exposição Ocupacional
/
Agricultura
/
Esclerose Lateral Amiotrófica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
/
Male
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos