Association of the red cell distribution width with red blood cell deformability.
Adv Exp Med Biol
; 765: 211-216, 2013.
Article
em En
| MEDLINE
| ID: mdl-22879035
ABSTRACT
The red cell distribution width (RDW) is a component of the automated complete blood count (CBC) that quantifies heterogeneity in the size of circulating erythrocytes. Higher RDW values reflect greater variation in red blood cell (RBC) volumes and are associated with increased risk for cardiovascular disease (CVD) events. The mechanisms underlying this association are unclear, but RBC deformability might play a role. CBCs were assessed in 293 adults who were clinically examined. RBC deformability (expressed as the elongation index) was measured using a microfluidic slit-flow ektacytometer. Multivariate regression analysis identified a clear threshold effect whereby RDW values above 14.0% were significantly associated with decreased RBC deformability (ß = -0.24; p = 0.003). This association was stronger after excluding anemic participants (ß = -0.40; p = 0.008). Greater variation in RBC volumes (increased RDW) is associated with decreased RBC deformability, which can impair blood flow through the microcirculation. The resultant hypoxia may help to explain the previously reported increased risk for CVD events associated with elevated RDW.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Doenças Cardiovasculares
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Tamanho Celular
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Índices de Eritrócitos
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Eritrócitos
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos