The checkpoint transcriptional response: make sure to turn it off once you are satisfied.
Cell Cycle
; 11(17): 3166-74, 2012 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-22895177
ABSTRACT
The replication checkpoint signaling network monitors the presence of replication-induced lesions to DNA and coordinates an elaborate cellular response that includes ample transcriptional reprogramming. Recent work has established two major groups of replication stress-induced genes in Saccharomyces cerevisiae, the DNA damage response (DDR) genes and G 1/S cell cycle (CC) genes. In both cases, transcriptional activation is mediated via checkpoint-dependent inhibition of a transcriptional repressor (Crt1 for DDR and Nrm1 for CC) that participates in negative feedback regulation. This repressor-mediated regulation enables transcription to be rapidly repressed once cells have dealt with the replication stress. The recent finding of a new class of CC genes, named "switch genes," further uncovers a mode of transcription regulation that prevents overexpression of replication stress induced genes during G 1. Collectively, these findings highlight the need for mechanisms that tightly control replication stress-induced transcription, allowing rapid transcriptional activation during replication stress but also avoiding long-term hyperaccumulation of the induced protein product that may be detrimental to cell proliferation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Transdução de Sinais
/
Ativação Transcricional
/
Genes de Troca
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Genes cdc
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Replicação do DNA
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Pontos de Checagem da Fase S do Ciclo Celular
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Cell Cycle
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos