Fabrication and characterisation of 2NDPA-loaded poly(lactide-co-glycolide) (PLG) microspheres for explosive safety.
J Microencapsul
; 29(6): 569-75, 2012.
Article
em En
| MEDLINE
| ID: mdl-22913470
ABSTRACT
We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The microsphere size was found to be inversely related to the mixing rate. It was also found that a higher theoretical loading of 2-NDPA resulted in larger microspheres. In addition, a Rosin Rammler distribution function gave an accurate representation of the microsphere size distribution, and the release rate 2-NDPA from PLG microspheres was found to be size dependent. We show that parameters such as the stirring speed and the percent loading of 2-NDPA can be varied to tailor the release of 2-NDPA from PLG microspheres. In addition, we have shown that temperature has a dramatic effect on the release of 2-NDPA from PLG microcapsules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Ácido Poliglicólico
/
Segurança
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Ácido Láctico
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Substâncias Explosivas
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Microesferas
Idioma:
En
Revista:
J Microencapsul
Assunto da revista:
FARMACIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos