Adiposity indices in the prediction of insulin resistance in prepubertal Colombian children.
Public Health Nutr
; 16(2): 248-55, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-22916737
ABSTRACT
OBJECTIVE:
To compare BMI with abdominal skinfold thickness (ASF), waist circumference and waist-to-height ratio in the prediction of insulin resistance (IR) in prepubertal Colombian children.DESIGN:
We calculated age- and sex-specific Z-scores for BMI, ASF, waist circumference, waist-to-height ratio and three other skinfold-thickness sites. Logistic regression with stepwise selection (P = 0·80 for entry and P = 0·05 for retention) was performed to identify predictors of IR and extreme IR, which were determined by age- and sex-specific Z-scores to identify the ≥ 90th and ≥ 95th percentile of homeostasis model assessment (HOMAIR), respectively. We used receiver operating characteristic curves to compare the area under the curve between models.SETTING:
Bucaramanga, Colombia.SUBJECTS:
Children (n 1261) aged 6-10 years in Tanner stage 1 from a population-based study.RESULTS:
A total of 127 children (seventy girls and fifty-seven boys) were classified with IR, including sixty-three children (thirty-three girls and thirty boys) classified with extreme IR. Only ASF and BMI Z-scores were retained as predictors of IR by stepwise selection. Adding ASF Z-score to BMI Z-score improved the area under the curve from 0·794 (95 % CI 0·752, 0·837) to 0·811 (95 % CI 0·770, 0·851; P for contrast = 0·01). In predicting extreme IR, the addition of ASF Z-score to BMI Z-score improved the area under the curve from 0·837 (95 % CI 0·790, 0·884) to 0·864 (95 % CI 0·823, 0·905; P for contrast = 0·01).CONCLUSIONS:
ASF Z-score predicted IR independent of BMI Z-score in our population of prepubertal children. ASF and BMI Z-scores together improved IR risk stratification compared with BMI Z-score alone, opening new perspectives in the prediction of cardiometabolic risk in prepubertal children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dobras Cutâneas
/
Resistência à Insulina
/
Índice de Massa Corporal
/
Gordura Intra-Abdominal
/
Adiposidade
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
En
Revista:
Public Health Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Ano de publicação:
2013
Tipo de documento:
Article