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Proteomic analyses of the vitreous humour.
Angi, Martina; Kalirai, Helen; Coupland, Sarah E; Damato, Bertil E; Semeraro, Francesco; Romano, Mario R.
Afiliação
  • Angi M; Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. m.angi@liverpool.ac.uk
Mediators Inflamm ; 2012: 148039, 2012.
Article em En | MEDLINE | ID: mdl-22973072
ABSTRACT
The human vitreous humour (VH) is a transparent, highly hydrated gel, which occupies the posterior segment of the eye between the lens and the retina. Physiological and pathological conditions of the retina are reflected in the protein composition of the VH, which can be sampled as part of routine surgical procedures. Historically, many studies have investigated levels of individual proteins in VH from healthy and diseased eyes. In the last decade, proteomics analyses have been performed to characterise the proteome of the human VH and explore networks of functionally related proteins, providing insight into the aetiology of diabetic retinopathy and proliferative vitreoretinopathy. Recent proteomic studies on the VH from animal models of autoimmune uveitis have identified new signalling pathways associated to autoimmune triggers and intravitreal inflammation. This paper aims to guide biological scientists through the different proteomic techniques that have been used to analyse the VH and present future perspectives for the study of intravitreal inflammation using proteomic analyses.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corpo Vítreo / Proteômica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mediators Inflamm Assunto da revista: BIOQUIMICA / PATOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corpo Vítreo / Proteômica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mediators Inflamm Assunto da revista: BIOQUIMICA / PATOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Reino Unido