Altered fear learning across development in both mouse and human.
Proc Natl Acad Sci U S A
; 109(40): 16318-23, 2012 Oct 02.
Article
em En
| MEDLINE
| ID: mdl-22988092
ABSTRACT
The only evidence-based behavioral treatment for anxiety and stress-related disorders involves desensitization techniques that rely on principles of extinction learning. However, 40% of patients do not respond to this treatment. Efforts have focused on individual differences in treatment response, but have not examined when, during development, such treatments may be most effective. We examined fear-extinction learning across development in mice and humans. Parallel behavioral studies revealed attenuated extinction learning during adolescence. Probing neural circuitry in mice revealed altered synaptic plasticity of prefrontal cortical regions implicated in suppression of fear responses across development. The results suggest a lack of synaptic plasticity in the prefrontal regions, during adolescence, is associated with blunted regulation of fear extinction. These findings provide insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Ansiedade
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Condicionamento Psicológico
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Extinção Psicológica
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Medo
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Plasticidade Neuronal
Limite:
Adolescent
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Adult
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Animals
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos