Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.
Exp Diabetes Res
; 2012: 470302, 2012.
Article
em En
| MEDLINE
| ID: mdl-22991506
ABSTRACT
microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null cells are depleted. Furthermore, wild-type beta cells are repopulating the islets in complex compensatory dynamics. Because loss of Dicer1 is also associated with changes in the distribution of membranous E-cadherin, we hypothesized that E-cadherin activity may play a role in beta cell survival or islet architecture. However, genetic loss of E-cadherin function does not impair islet architecture, suggesting that miRNAs likely function through other or redundant effectors in the endocrine pancreas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Intolerância à Glucose
/
MicroRNAs
/
Ribonuclease III
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Células Secretoras de Insulina
/
RNA Helicases DEAD-box
Limite:
Animals
Idioma:
En
Revista:
Exp Diabetes Res
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Israel