Aldosterone antagonists. 3. Synthesis and activities of steroidal 7 alpha-(alkoxycarbonyl)-15,16-methylene spirolactones.
J Med Chem
; 33(2): 509-13, 1990 Feb.
Article
em En
| MEDLINE
| ID: mdl-2299621
ABSTRACT
Several A- and D-ring substituted steroidal 7 alpha-alkoxycarbonyl spirolactones were synthesized with the purpose of increasing the aldosterone antagonistic potency and reducing the endocrinological side effects relative to the standard drug spironolactone. It was found that the 15 beta,16 beta-methylene derivative 17 exhibited a 2-fold higher aldosterone antagonistic activity compared to either spironolactone or the 15,16-unsubstituted derivative 29 while showing remarkably reduced antiandrogenicity.
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Base de dados:
MEDLINE
Assunto principal:
Pregnadienos
/
Espironolactona
/
Antagonistas de Receptores de Mineralocorticoides
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1990
Tipo de documento:
Article