Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.
Brain Res
; 1483: 112-7, 2012 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-23000195
ABSTRACT
In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Regulação para Cima
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Proteínas de Choque Térmico
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Esclerose Lateral Amiotrófica
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Antioxidantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2012
Tipo de documento:
Article