Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells.
Cell Signal
; 25(1): 206-13, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23000344
ABSTRACT
Here we studied the cellular mechanisms of ursolic acid's anti-bladder cancer ability by focusing on endoplasmic reticulum stress (ER stress) signaling. We show that ursolic acid induces a significant ER stress response in cultured human bladder cancer T24 cells. ER stress inhibitor salubrinal, or PERK silencing, diminishes ursolic acid-induced anti-T24 cell effects. Salubrinal inhibits ursolic acid-induced CHOP expression, Bim ER accumulation and caspase-3 activation in T24 cells. Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. We suggest that ER stress contributes to ursolic acid's effects against bladder cancer cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Apoptose
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MAP Quinase Quinase Quinase 5
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Retículo Endoplasmático
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Estresse do Retículo Endoplasmático
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Cell Signal
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China