The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Nat Immunol
; 13(11): 1092-100, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-23001146
ABSTRACT
Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell-dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this process has been questioned. Here we identified c-Myc(+) B cell subpopulations in immature and mature GCs and found, by genetic ablation of Myc, that they had indispensable roles in the formation and maintenance of GCs. The identification of these functionally critical cellular subsets has implications for human B cell lymphomagenesis, which originates mostly from GC B cells and frequently involves MYC chromosomal translocations. As these translocations are generally dependent on transcription of the recombining partner loci, the c-Myc(+) GC subpopulations may be at a particularly high risk for malignant transformation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Ciclo Celular
/
Subpopulações de Linfócitos B
/
Proteínas Proto-Oncogênicas c-myc
/
Centro Germinativo
Limite:
Animals
Idioma:
En
Revista:
Nat Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos