[Effects of Xinjierkang on two kidney one clip-induced hypertension and target organ injury in rats].
Zhong Yao Cai
; 35(4): 591-5, 2012 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-23019907
ABSTRACT
OBJECTIVE:
To investigate the effects of Xinjierkang on two kidney one clip -induced hypertension and target organ injury in rats.METHODS:
Two kidney one clip-induced hypertension rats model was established. Rats were divided into control group, model group, Xinjierkang group, and fosinopril group. At the end of 8th w, the hemodynamics indexes were recorded. The cardiac hypertrophy index was expressed as heart weight/body weight (HW/BW), the histological changes of heart, aorta and kidney were investigated by HE and/or Van Gieson stain.RESULTS:
Compared with control group, the heart systolic and diastolic function were impaired, the heart weight index, cardiomyocytes cross section area (CSA), cardiac collagen deposition, vascular remodeling index and glomerulus area were increased markedly in model group rats. Administration of Xinjierkang and fosinopril markedly ameliorated hemodynamic indexes, inhibited the elevation of HW/BW ratio, CSA of cardiomyocytes, vascular remodeling index and glomerulus hypertrophy, decreased collagen deposition in heart.CONCLUSION:
Xinjierkang has protective effects against two kidney one clip-induced hemodynamic impairment, cardiovascular remodeling and glomerulus hypertrophy in rats.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Remodelação Ventricular
/
Hipertensão Renal
/
Glomérulos Renais
/
Miocárdio
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
Zh
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China