Glutamate-gated chloride channels.
J Biol Chem
; 287(48): 40232-8, 2012 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-23038250
ABSTRACT
Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla but are closely related to mammalian glycine receptors. They have a number of roles in these animals, controlling locomotion and feeding and mediating sensory inputs into behavior. In nematodes and arthropods, they are targeted by the macrocyclic lactone family of anthelmintics and pesticides, making the GluCls of considerable medical and economic importance. Recently, the three-dimensional structure of a GluCl was solved, the first for any eukaryotic ligand-gated anion channel, revealing a macrocyclic lactone-binding site between the channel domains of adjacent subunits. This minireview will highlight some unique features of the GluCls and illustrate their contribution to our knowledge of the entire Cys loop ligand-gated ion channel superfamily.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Helminto
/
Canais de Cloreto
/
Proteínas de Insetos
/
Insetos
/
Nematoides
Limite:
Animals
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos