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[Bone mineral density of young women with history of anorexia nervosa]. / Beinthéttni ungra kvenna med sögu um lystarstol.
Runarsdottir, Rebekka Guðrun; Thorsteinsdottir, Gudlaug; Indridason, Olafur Skuli; Sigurdsson, Gunnar.
Afiliação
  • Runarsdottir RG; Faculty of Medicine, University of Iceland, Iceland.
Laeknabladid ; 98(10): 523-9, 2012 10.
Article em Is | MEDLINE | ID: mdl-23043065
ABSTRACT

OBJECTIVE:

A decrease in bone mineral density (BMD) is frequently seen in patients with anorexia nervosa (AN). This study was designed to assess BMD of young Icelandic women with current or previous history of AN and identify predictors which might be targets for preventive measures. MATERIAL AND

METHODS:

The study was retrospective. Participants were women aged 18-40 years, with diagnosis of AN (F50.0, F50.1) attending the anorexia unit at Landspítali - The National University Hospital of Iceland - in 2001-2009, who had undergone measurement of BMD by dual-energy X-ray absorptiometry. A control group consisted of 58 healthy 30 years old women participating in a study of bone health in 2001-2003.

RESULTS:

At time of BMD measurement the median body mass index (BMI kg/m2) in the AN group (n=40) was 17.4 (12.3-25.2) compared to 23.6 (18.1-43.7) in the control group (p<0,001). Lumbar spine and hip BMD were 15.3-17.5% lower in AN patients than in control subjects (p<0.001). In both groups there was a strong correlation between BMD and body weight (r=0.354-0.604, p<0.05) and lean mass (r=0.425-0.588, p<0.05). Among patients with AN a correlation was also seen between BMD and lowest weight during the illness (r=0.482-0.499, p<0.01). Among the 26 AN patients who had repeated BMD measurement, a significant decrease in BMD at femoral neck (-6.6%, p=0.030) was observed in those who lost weight between the measurements (n=9). Those who had BMI ≤17.5 between BMD measurements lost 5.5-7.1% of the BMD at the hip (p<0.05).

CONCLUSION:

Young women with AN have 15% lower bone mass than healthy young women. The relationship between BMD and body weight seems to be a continuum across disease states. Increased body weight may be the most important factor for recovery of bone mass in AN patients.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osso e Ossos / Doenças Ósseas / Anorexia Nervosa / Densidade Óssea Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans País/Região como assunto: Europa Idioma: Is Revista: Laeknabladid Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Islândia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osso e Ossos / Doenças Ósseas / Anorexia Nervosa / Densidade Óssea Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans País/Região como assunto: Europa Idioma: Is Revista: Laeknabladid Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Islândia