Pd-catalyzed Suzuki coupling reaction of chloroalkylidene-ß-lactones with LB-Phos as the ligand.

ABSTRACT

In this paper, LB-Phos·HBF(4) salt has been applied for the Pd-catalysed Suzuki coupling reactions of optically active (Z)-α-choroalkylidene-ß-lactones. Aryl, vinyl, alkyl and heteroaromatic boronic acids may be coupled with optically active ß-lactones affording corresponding optically active products highly selectively and efficiently.