Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.
Phytochemistry
; 85: 122-8, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23098899
ABSTRACT
Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4ß-hydroxy-1α,5ßH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4ß,7ßH-guai-10(15)-en- 5ß,8ß-endoxide(3), 7ß,8α-dihydroxy-1α,4αH-guai-10(15)-en-5ß,8ß-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC50 values ranged from 6.80 to 39.97 µM, and SI values ranged from 6.35 to 37.25.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Curcuma
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Influenza Humana
Limite:
Animals
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Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2013
Tipo de documento:
Article