Carbon nanotubes functionalized with sodium hyaluronate restore bone repair in diabetic rat sockets.
Oral Dis
; 19(5): 484-93, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23107153
ABSTRACT
OBJECTIVE:
We evaluated the effects of sodium hyaluronate (HY) and carbon nanotubes functionalized with HY (HY-CNT) on bone repair in the tooth sockets of diabetic rats. MATERIALS ANDMETHODS:
Diabetes was induced by streptozotocin (50 mg kg(-1) i.v.), and the sockets were divided into normal control, diabetic control, diabetic treated with HY (1%), and diabetic treated with HY-CNT (100 µg ml(-1)) groups. The sockets were analyzed according to the percentage of bone formation and the number of cell nuclei.RESULTS:
The percentage of bone trabeculae was lower in diabetic control animals (11.16 ± 5.10% vs 41.92 ± 6.34% in normal animals) after 14 days. Treating diabetic animals with HY or HY-CNT significantly increased the percentage of neoformed trabeculae (HY 29.43 ± 3.29%; HY-CNT 36.90 ± 3.07%). Moreover, the sockets of diabetic animals had an increased number of cell nuclei and HY or HY-CNT reduced this parameter.CONCLUSION:
Our results indicate that HY and HY-CNT restore bone repair in the tooth sockets of diabetic rats, suggesting that these biomaterials are potential adjuvant therapies for the management of diabetes.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração Óssea
/
Alvéolo Dental
/
Nanotubos de Carbono
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Diabetes Mellitus Experimental
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Ácido Hialurônico
Limite:
Animals
Idioma:
En
Revista:
Oral Dis
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil