Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
Neurology
; 40(3 Pt 1): 456-60, 1990 Mar.
Article
em En
| MEDLINE
| ID: mdl-2314588
ABSTRACT
ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.
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Base de dados:
MEDLINE
Assunto principal:
Fenitoína
/
Pró-Fármacos
/
Epilepsia
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1990
Tipo de documento:
Article