Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs.
Chem Soc Rev
; 42(2): 755-73, 2013 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-23147001
ABSTRACT
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-containing complexes as potential anticancer drugs. Among these novel complexes, metal N-heterocyclic carbene (NHC) complexes have recently gained considerable attention because they perfectly fit prerequisites for efficient drug design and fast optimization. Moreover, most of them have shown higher cytotoxicity than cisplatin. This review describes the advances that have been achieved in using transition metal (Ag, Au, Pt, Pd, Cu, Ni, and Ru) complexes containing NHC ligands as antitumor agents. Their modes of action at the cellular lever are further discussed. All these initial achievements clearly demonstrate the great potential of metal-NHC complexes as antitumor agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexos de Coordenação
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Metano
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Neoplasias
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Chem Soc Rev
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha