Role of the TNFA -308G > A polymorphism in the genetic susceptibility to acne vulgaris in a Sicilian population.
Ann Ig
; 24(5): 351-7, 2012.
Article
em En
| MEDLINE
| ID: mdl-23193891
ABSTRACT
BACKGROUND:
Acne vulgaris is a common and clinically well-characterized skin disease that affects a great proportion of the general population and thus, is a major public health problem. The aim of the present study was to investigate whether TNFA -308 G > A polymorphism might be involved in the pathogenesis of acne in a population from Sicily.METHODS:
A total of 74 patients with acne and of 88 healthy control subjects from Catania, Italy were examined in the present study. TNFA -308 G > A polymorphisms using the PCR-RFLP method were determined in DNA extracted from buccal swabs.RESULTS:
When controls were compared to acne patients, their genotype distributions, respectively G/G 64.3%, G/A 35.7% and G/G 74.0%, G/A 26.0%, were shown to be different, although not statistically significant (p = 0.191). A significant protective association between the TNFA -308 GA genotype and acne in males (p = 0.027; OR95% CI 0.288; 0.094-0.889) was shown.CONCLUSIONS:
The present results suggest that TNFA -308 polymorphism may contribute to acne susceptibility, as suggested by the protective effect of the G/A phenotype in the males of the Sicilian cohort. Further studies in larger groups, investigating the TNFA -308G/A or other polymorphisms of this gene in acne patients may be helpful to clarify the pathogenesis of the disease.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Fator de Necrose Tumoral alfa
/
Acne Vulgar
/
Predisposição Genética para Doença
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ann Ig
Assunto da revista:
MICROBIOLOGIA
/
SAUDE PUBLICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália