p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP1.
Med Sci Monit
; 18(12): CR712-5, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23197232
ABSTRACT
BACKGROUND:
Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP1) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP1 is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD. MATERIAL/METHODS:
The study included 381 patients admitted to the hospital for cardiovascular disease (232 patients with CAD and 149 with other cardiovascular problems) and 97 healthy newborns.RESULTS:
The proportion of subjects carrying the *Pro allele of p53 codon 72 and the high activity *B*C genotype of ACPACP1 is higher in CAD (10.3%) than in non-CAD patients (2.0%) and in healthy newborns (6.2%).CONCLUSIONS:
The data suggest an interaction between p53 codon 72 and ACPACP1 wherein a positive effect of the p53 *Pro allele on susceptibility to CAD occurs, but only in the presence of the ACPACP1 genotype characterized by high enzymatic activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Códon
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Proteína Supressora de Tumor p53
/
Proteínas Proto-Oncogênicas
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Proteínas Tirosina Fosfatases
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
Limite:
Aged
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Female
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Humans
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Male
/
Newborn
Idioma:
En
Revista:
Med Sci Monit
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália