Formulation optimization of a palm-based nanoemulsion system containing levodopa.
Int J Mol Sci
; 13(10): 13049-64, 2012 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-23202937
ABSTRACT
Response surface methodology (RSM) was utilized to investigate the influence of the main emulsion composition; mixture of palm and medium-chain triglyceride (MCT) oil (6%-12% w/w), lecithin (1%-3% w/w), and Cremophor EL (0.5%-1.5% w/w) as well as the preparation method; addition rate (2-20 mL/min), on the physicochemical properties of palm-based nanoemulsions. The response variables were the three main emulsion properties; particle size, zeta potential and polydispersity index. Optimization of the four independent variables was carried out to obtain an optimum level palm-based nanoemulsion with desirable characteristics. The response surface analysis showed that the variation in the three responses could be depicted as a quadratic function of the main composition of the emulsion and the preparation method. The experimental data could be fitted sufficiently well into a second-order polynomial model. The optimized formulation was stable for six months at 4 °C.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
/
Levodopa
/
Nanoestruturas
/
Emulsões
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Malásia