Your browser doesn't support javascript.
loading
Temporal discrimination in patients with dystonia and tremor and patients with essential tremor.
Tinazzi, Michele; Fasano, Alfonso; Di Matteo, Alessandro; Conte, Antonella; Bove, Francesco; Bovi, Tommaso; Peretti, Alessia; Defazio, Giovanni; Fiorio, Mirta; Berardelli, Alfredo.
Afiliação
  • Tinazzi M; Department of Neurological, Psychological, Morphological and Motor Sciences, University of Verona, Verona, Italy.
Neurology ; 80(1): 76-84, 2013 Jan 01.
Article em En | MEDLINE | ID: mdl-23243072
ABSTRACT

OBJECTIVE:

To investigate whether psychophysical techniques assessing temporal discrimination could help in differentiating patients who have tremor associated with dystonia or essential tremor.

METHODS:

We tested somatosensory temporal discrimination thresholds (TDT) and temporal discrimination movement thresholds (TDMT) in 39 patients who had tremor associated with dystonia or essential tremor presenting with upper-limb tremor of comparable severity and compared their findings with those from a group of 25 sex- and age-matched healthy control subjects.

RESULTS:

TDT was higher in patients who had tremor associated with dystonia than in those with essential tremor and healthy controls (110.6 ± 31.3 vs 63.1 ± 15.2 vs 62.4 ± 9.2; p < 0.001). Conversely, TDMT was higher in patients with essential tremor than in those with tremor associated with dystonia and healthy controls (113.7 ± 14.7 vs 103.4 ± 11.3 vs 100.4 ± 4.2; p < 0.001). Combining the 2 tests in a pattern for essential tremor (abnormal TDMT/normal TDT) and tremor associated with dystonia (normal TDMT/abnormal TDT) yielded a positive predictive value (PPV) of 86.7% and a negative predictive value (NPV) of 70.8% for diagnosing essential tremor and a PPV of 100.0% and NPV of 74.1% for diagnosing tremor associated with dystonia.

CONCLUSIONS:

TDT and TDMT testing should prove a useful tool for differentiating tremor associated with dystonia and essential tremor. Our findings imply that the pathophysiologic mechanisms underlying tremor associated with dystonia differ from those for essential tremor.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Limiar Sensorial / Percepção do Tempo / Tremor / Tremor Essencial / Discriminação Psicológica / Distonia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Limiar Sensorial / Percepção do Tempo / Tremor / Tremor Essencial / Discriminação Psicológica / Distonia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Itália