Structure of the O-glycosylated conopeptide CcTx from Conus consors venom.
Chemistry
; 19(3): 870-9, 2013 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-23281027
ABSTRACT
The glycopeptide CcTx, isolated from the venom of the piscivorous cone snail Conus consors, belongs to the κA-family of conopeptides. These toxins elicit excitotoxic responses in the prey by acting on voltage-gated sodium channels. The structure of CcTx, a first in the κA-family, has been determined by high-resolution NMR spectroscopy together with the analysis of its O-glycan at Ser7. A new type of glycopeptide O-glycan core structure, here registered as core typeâ
9, containing two terminal L-galactose units {α-L-Galp-(1â4)-α-D-GlcpNAc-(1â6)-[α-L-Galp-(1â2)-ß-D-Galp-(1â3)-]α-D-GalpNAc-(1âO)}, is highlighted. A sequence comparison to other putative members of the κA-family suggests that O-linked glycosylation might be more common than previously thought. This observation alone underlines the requirement for more careful and in-depth investigations into this type of post-translational modification in conotoxins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicopeptídeos
/
Caramujo Conus
/
Venenos de Moluscos
Limite:
Animals
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda