Borderline personality traits and substance use: genetic factors underlie the association with smoking and ever use of cannabis, but not with high alcohol consumption.
J Pers Disord
; 26(6): 867-79, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23281672
ABSTRACT
Borderline personality disorder (BPD) and substance use disorders often co-occur. Both disorders are heritable and family studies showed that there are familial factors that increase the risk for BPD as well as substance use/abuse. This is the first study that investigates whether the association of borderline personality traits (BPT) with substance use reflects an underlying genetic vulnerability or nongenetic familial influences. To this end we analyzed data of 5,638 Dutch and Belgian twins aged between 21-50 years from 3,567 families. Significant associations between BPT and high alcohol consumption (r = .192), regular smoking (r = .299), and ever use of cannabis (r = .254) were found. Bivariate genetic analyses showed that the associations of BPT and substance use had different etiologies. For regular smoking and for ever use of cannabis, the correlation with BPT was explained by common genetic factors. Interestingly, for high alcohol consumption and BPT the association was explained by unique environmental factors that influence both traits rather than common genetic factors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Personalidade
/
Transtorno da Personalidade Borderline
/
Consumo de Bebidas Alcoólicas
/
Fumar Maconha
/
Fumar
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pers Disord
Assunto da revista:
PSICOLOGIA
/
PSIQUIATRIA
/
TRANSTORNOS MENTAIS
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Holanda