Hydroxyurea treatment in ß-thalassemia patients: to respond or not to respond?
Ann Hematol
; 92(3): 289-99, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23318979
ABSTRACT
Hydroxyurea (HU) is a drug that induces fetal hemoglobin production. As a result, HU is widely used to treat ß-thalassemia (ß-thal) patients. However, the response of these patients to HU varies. Some ß-thal patients respond favorably to treatment while others do not respond at all. HU has a number of side-effects and therefore its targeted prescription is beneficial. Hence, identifying the genetic determinants which lead to the differential HU response is important. This review summarizes recent findings which have shed light on this topic. Special emphasis is given to the mechanisms and genetic loci which may govern these differences. These findings have helped identify several single nucleotide polymorphisms which associate with the response to HU in both ß-thal and sickle cell disease patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Talassemia beta
/
Hidroxiureia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann Hematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Irã