The neural basis of difficulties disengaging from negative irrelevant material in major depression.
Psychol Sci
; 24(3): 334-44, 2013 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-23334445
ABSTRACT
Recurrent uncontrollable negative thoughts are a hallmark of depressive episodes. Deficits in cognitive control have been proposed to underlie this debilitating aspect of depression. Here, we used functional neuroimaging during an emotional working memory (WM) task to elucidate the neural correlates of these difficulties in cognitive control. In a WM manipulation involving depressed participants, the dorsal anterior cingulate and parietal and bilateral insular cortices were activated significantly more when negative words were removed from WM than when they were maintained in WM; in contrast, nondepressed participants exhibited stronger neural activations in these regions for positive than for negative material. These findings implicate anomalous activation of components of the task-positive network, known to be modulated by cognitive effort, in depression-associated difficulties in expelling negative material from WM. Future studies should examine the association between these aberrations and the maintenance of depressive symptoms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Transtorno Depressivo Maior
/
Emoções
/
Memória de Curto Prazo
/
Rede Nervosa
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychol Sci
Assunto da revista:
PSICOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos