Differences in resting corticolimbic functional connectivity in bipolar I euthymia.
Bipolar Disord
; 15(2): 156-66, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23347587
ABSTRACT
OBJECTIVE:
We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects.METHODS:
Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting state functional magnetic resonance imaging scan. Low-frequency fluctuations in blood oxygen level-dependent (BOLD) signal were correlated in the six connections between four anatomically defined nodes left and right amygdala and left and right ventrolateral prefrontal cortex (vlPFC). Seed-to-voxel connectivity results were probed for commonly coupled regions. Following this, an identified region was included in a mediation analysis to determine the potential of mediation.RESULTS:
The bipolar I disorder group exhibited significant hyperconnectivity between right amygdala and right vlPFC relative to healthy subjects. The connectivity between these regions in the bipolar I disorder group was partially mediated by activity in the anterior cingulate cortex (ACC).CONCLUSIONS:
Greater coupling between right amygdala and right vlPFC and their partial mediation by the ACC were found in bipolar I disorder subjects in remission and in the absence of a psychological task. These findings have implications for a trait-related and clinically important imaging biomarker.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Descanso
/
Transtorno Bipolar
/
Córtex Cerebral
/
Sistema Límbico
/
Vias Neurais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Bipolar Disord
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos