Hb Treviso [α91(FG3)LeuâPhe (α2)]: a new slightly unstable hemoglobin variant with moderately decreased oxygen affinity.
Hemoglobin
; 37(2): 107-11, 2013.
Article
em En
| MEDLINE
| ID: mdl-23350769
ABSTRACT
We report a new hemoglobin (Hb) variant, found in a North-East Italian family living in the city of Treviso. The proband, a non anemic 60-year-old male with a history of chronic rhinitis, allergy to Parietaria and suspected obstructive sleep apnea syndrome, was referred for blood gas analysis. Determination of the oxygen affinity revealed a p50 of 32.5 mmHg (control 27.5 mmHg) indicating a moderate decrease in oxygen affinity. An abnormal pattern compatible with an α Hb variant was observed on high performance liquid chromatography (HPLC); direct sequencing revealed a transition at codon 91 of the α2 gene (HBA2 c.274C>T) changing leucine into phenylalanine. Characterization and phenotype studies are reported.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemoglobina A2
/
Hemoglobinas Anormais
/
Mutação de Sentido Incorreto
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hemoglobin
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália