The genetic contribution to severe post-traumatic osteoarthritis.
Ann Rheum Dis
; 72(10): 1687-90, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23355107
ABSTRACT
OBJECTIVE:
to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.METHODS:
A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates.RESULTS:
For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10â»5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10â»5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063).CONCLUSIONS:
Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite do Quadril
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Osteoartrite do Joelho
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Lesões do Quadril
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Traumatismos do Joelho
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido