Role of p90(RSK) in regulating the Crabtree effect: implications for cancer.
Biochem Soc Trans
; 41(1): 124-6, 2013 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-23356270
ABSTRACT
High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a potential upstream mediator of the effects of high glucose. Evidence is also emerging that p90(RSK) may play a role in cancer cell signalling, although the role of p90(RSK) in regulating cancer cell metabolism is unclear. In the present paper, we provide an overview of the Crabtree effect and its relationship to mitochondrial metabolism. Furthermore, preliminary data are presented suggesting a role for p90(RSK) and its upstream components, the ERK (extracellular-signal-regulated kinase) family of MAPKs (mitogen-activated protein kinases), in the Crabtree effect.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases S6 Ribossômicas 90-kDa
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos