Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle.
J Mol Cell Cardiol
; 58: 53-8, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23369697
ABSTRACT
In cardiac muscle cells, ryanodine receptor (RyR) mediated Ca(2+) release from the sarcoplasmic reticulum (SR) drives the contractile apparatus. Spontaneous bouts of inter-RyR Ca(2+) induced Ca(2+) release (CICR) generate an elemental unit of SR Ca(2+) release called a spark. Sparks are localized events that terminate soon after they begin. The local control of sparks is not clearly understood. In this article, we review the potential regulatory role that the changing single RyR Ca(2+) current may play. Moreover, we aggregate RyR data into a working scheme of inter-RyR CICR current control of sparks and a potential inter-RyR CICR termination mechanism that we call pernicious attrition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
Sinalização do Cálcio
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Miocárdio
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos