CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
J Immunol
; 190(6): 2828-34, 2013 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-23382562
ABSTRACT
CD4(+) memory-phenotype T cells decline over time when generated in response to acute infections cleared by other components of the immune system. Therefore, it was of interest to assess the stability of CD4(+) T cells during a persistent Salmonella infection, which is typical of persistent phagocytic infections that are controlled by this lymphocyte subset. We found that CD4(+) T cells specific for Salmonella peptideMHC class II (MHCII) ligands were numerically stable for >1 y after initial oral infection. This stability was associated with peptideMHCII-driven proliferation by a small number of T cells in the secondary lymphoid organs that harbored bacteria. The persistent population consisted of multifunctional Th1 cells that induced PD-1 and became exhausted when transferred to hosts expressing the specific peptideMHCII ligand in all parts of the body. Thus, persistent infection of phagocytes produced a CD4(+) T cell population that was stably maintained by low-level peptideMHCII presentation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Infecções por Salmonella
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Linfócitos T CD4-Positivos
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Antígenos de Histocompatibilidade Classe II
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Apresentação de Antígeno
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos