Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara.
J Nat Prod
; 76(2): 194-9, 2013 Feb 22.
Article
em En
| MEDLINE
| ID: mdl-23387901
ABSTRACT
From an endophytic fungus, a close relative of Talaromyces sp., found in association with Cedrus deodara, four compounds including two new ones (2 and 4) were isolated and characterized. The structures of two compounds (1 and 4) were confirmed by X-ray crystallography. The compounds displayed a range of cytotoxicities against human cancer cell lines (HCT-116, A-549, HEP-1, THP-1, and PC-3). All the compounds were found to induce apoptosis in HL-60 cells, as evidenced by fluorescence and scanning electron microscopy studies. Also, the compounds caused significant microtubule inhibition in HL-60 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Cedrus
/
Isocumarinas
/
Moduladores de Tubulina
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia