[Teratogenic studies on stannous chloride in rats].

ABSTRACT

This paper describes teratogenic studies of stannous chloride in rats. The compound was administered to pregnant rats on gestational days 7 through 12 orally by a stomach tube at dose levels of 0 mg, 20 mg, 100 mg, 500 mg/kg of stannous chloride and fish liver oil for the positive control group. The experimental results showed that the placenta not only retains some stannous chloride but also diverts parts of the stannous chloride is the fetus. Stannous chloride showed teratogenic effects on the early growing embryos and protruding tongue of fetus.