RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-ß-catenin signaling.
Science
; 339(6126): 1436-41, 2013 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-23413191
ABSTRACT
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-ß-catenin network, where it acts as a regulatory subunit of CK1ε In a Wnt-dependent manner, DDX3 binds CK1ε and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-ß-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Helicases
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Proteínas de Xenopus
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Caseína Quinase 1 épsilon
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RNA Helicases DEAD-box
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Via de Sinalização Wnt
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha