Niacin induced coagulopathy as a manifestation of occult liver injury.
W V Med J
; 109(1): 12-4, 2013.
Article
em En
| MEDLINE
| ID: mdl-23413541
ABSTRACT
Niacin is an effective lipid-lowering agent which occasionally may cause hepatic failure. Liver enzymes are periodically tested during niacin therapy to assess for hepatic injury. We report a case of suppressed synthesis of hepatically derived coagulation factors and other liver proteins in a patient on niacin with no elevation of hepatic aminotransferases. The protein abnormalities reversed rapidly on discontinuation of niacin. It appears that niacin can cause occult liver injury without frank aminotransferase elevations, and may portend severe hepatotoxicity. Periodic assessment of prothrombin time should be considered in addition to aminotransferase levels to screen for liver injury. We believe this is the first reported case of occult hepatic injury due to extended release niacin, presenting as coagulopathy.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Fatores de Coagulação Sanguínea
/
Doença Hepática Induzida por Substâncias e Drogas
/
Niacina
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
W V Med J
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos