Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy.
J Am Acad Dermatol
; 69(1): 120-6, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23415460
ABSTRACT
BACKGROUND:
Differentiation between seborrheic keratosis (SK) and skin cancers may be difficult. Reflectance confocal microscopy (RCM) enables noninvasive assessment of skin neoplasms at cellular-level resolution.OBJECTIVE:
We sought to describe RCM features of SK and to correlate these RCM findings with dermoscopic structures.METHODS:
Clinical, dermoscopic, and RCM images of 45 consecutive SK were obtained at a private and university dermatology clinic. Fourteen SK were biopsied because of equivocal clinical or dermoscopic features.RESULTS:
With RCM, all SK displayed a regular honeycomb pattern of the epidermis and densely packed, round to polymorphous, well-circumscribed dermal papillae at the dermoepidermal junction, features suggestive of a benign neoplasm. RCM features indicating the diagnosis of SK were also observed, including epidermal projections (43/45 SK; 96%) and keratin-filled invaginations (36/45 SK; 80%) at the lesion surface; corneal pseudocysts at epidermal layers (19/45 SK; 42%); and melanophages (21/45 SK; 47%) and dilated round and linear blood vessels (21/45 SK; 47%) in the papillary dermis. Of biopsied SK, 93% (13/14) displayed at least 3 characteristic RCM findings in the absence of RCM features suggestive of malignancy.LIMITATIONS:
This was a limited study sample and retrospective study design.CONCLUSIONS:
SK display a distinct set of RCM criteria despite their variable clinical and dermoscopic appearances.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Ceratose Seborreica
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Microscopia Confocal
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Dermoscopia
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
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Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Áustria