Your browser doesn't support javascript.
loading
Pulmonary resection after chemoradiotherapy for advanced non-small cell lung cancer: the impact of presurgical radiation therapy.
Shiraishi, Takeshi; Hiratsuka, Masafumi; Yanagisawa, Jun; Miyahara, Sou; Yoshida, Yasuhiro; Makimoto, Yoshifumi; Hamatake, Daisuke; Yamashita, Shin-ichi; Iwasaki, Akinori.
Afiliação
  • Shiraishi T; Department of General Thoracic, Breast, and Pediatric Surgery, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan, tshiraishi-ths@umin.ac.jp.
Surg Today ; 44(1): 123-30, 2014 Jan.
Article em En | MEDLINE | ID: mdl-23420096
ABSTRACT

PURPOSE:

Chemoradiation therapy (CRT) is recommended as standard care for stage III non-small cell lung cancer (NSCLC), but some patients experience local recurrence after the treatment. Surgical resection after CRT involves high surgical risk, but is expected to increase the curability. This study was performed to investigate the impact of presurgical CRT on the postoperative outcome, focusing especially on the effect of radiation therapy.

METHODS:

Twenty-six patients with stage III (N2 or T3-4) NSCLC underwent pulmonary resection after CRT. A radiation dose up to 40-70 Gy was given with concurrent chemotherapy. The morbidity, mortality and survival after surgical resection were examined.

RESULTS:

Lung resection was performed as lobectomy (73 %) or pneumonectomy (19 %). Postoperative complications occurred in 12 patients (morbidity 46.1 %). The overall 5-year survival of the entire cohort was 69.7 %. The factors associated with favorable long-term survival included a pathological complete response (CR) and mediastinal node negative condition after CRT, and microscopic complete resection.

CONCLUSION:

Surgical resection for stage III patients after CRT may provide a survival benefit with acceptable morbidity. The surgical morbidity may be increased by prior radiation therapy, thus, surgeons should be familiar with the available countermeasures to reduce the surgical risk.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonectomia / Cuidados Pré-Operatórios / Carcinoma Pulmonar de Células não Pequenas / Quimiorradioterapia Adjuvante / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Today Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonectomia / Cuidados Pré-Operatórios / Carcinoma Pulmonar de Células não Pequenas / Quimiorradioterapia Adjuvante / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Today Ano de publicação: 2014 Tipo de documento: Article